tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate
CAS No.:191613-90-8
Molecular Formula:C₂₃H₃₁NO₅
Molecular Weight:401.503
Hs Code.:

Synonyms:tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

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Chemical Property of tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

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Technology Process of tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

There total 5 articles about tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 191613-89-5
(R)-4-benzyl-3-(2-cyclopentylacetyl)oxazolidin-2-one

: 191613-90-8
tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

Guidance literature:: (R)-4-benzyl-3-(2-cyclopentylacetyl)oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 12h; diastereoselective reaction;
DOI:10.1016/j.ejmech.2018.08.052

Reference yield: 93.0%

: 191613-90-8
tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

In tetrahydrofuran; at -78 - 20 ℃; for 12h;

Reference yield:

: 1123-00-8
2-cyclopentylacetic acid

: 191613-90-8
tert-butyl (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-cyclopentyl-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pivaloyl chloride, Et₃N, n-BuLi / tetrahydrofuran / -78 - 20 °C

2: NaHMDS / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(98)00218-2