methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

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Chemical Name:methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate
CAS No.:1445589-59-2
Molecular Formula:C₄₀H₄₄N₈O₄
Molecular Weight:700.841
Hs Code.:

methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

Synonyms:methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

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Chemical Property of methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

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Technology Process of methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

There total 9 articles about methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

: 504-29-0
2-aminopyridine

: 1445591-93-4
(1R,2R)-tert-butyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

: 1445589-59-2
methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 40 - 50 ℃; for 0.166667h;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1445589-59-2
methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: bromine / chloroform / 0 - 20 °C

1.2: 6 h / 0 °C

1.3: pH 5

2.1: acetic anhydride / 20 h / Reflux

3.1: quinine / toluene; tetrachloromethane / 60 h / -65 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

5.1: acetonitrile / 5 h / 20 °C / Inert atmosphere

6.1: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

7.1: hydrogenchloride / water / 2 h / 80 °C

8.1: sulfuric acid / dichloromethane; 1,4-dioxane / -10 °C

9.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 40 - 50 °C

With hydrogenchloride; sulfuric acid; ammonium acetate; bromine; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1461-96-7
cis-1,2-cyclopentanedicarboxylic acid

: 1445589-59-2
methyl ((S)-3-methyl-1-oxo-1-((S)-2-(5-(4-(2-((1R,2R)-2-(pyridin-2-ylcarbamoyl)cyclopentyl)-1H-imidazol-5-yl)-[1,1’-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: acetic anhydride / 20 h / Reflux

2: quinine / toluene; tetrachloromethane / 60 h / -65 °C

3: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

4: acetonitrile / 5 h / 20 °C / Inert atmosphere

5: ammonium acetate / toluene / 6 h / 100 °C / Sealed tube

6: hydrogenchloride / water / 2 h / 80 °C

7: sulfuric acid / dichloromethane; 1,4-dioxane / -10 °C

8: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 40 - 50 °C

With hydrogenchloride; sulfuric acid; ammonium acetate; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;