{5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid

Base Information

• Chemical Name: {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid
• CAS No.: 861905-39-7
• Molecular Formula: C₁₀H₁₃BFNO₃
• Molecular Weight: 225.028
• Mol file: 861905-39-7.mol

Synonyms:{5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid

Chemical Property of {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid

There total 2 articles about {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Triisopropyl borate (5419-55-6) → {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid (861905-39-7)

Guidance literature:

N-ethyl-3-fluoro-5-iodo-4-methylbenzamide; With sodium hydride; In tetrahydrofuran;

With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 0.333333h;

Triisopropyl borate; With water; more than 3 stages;

Reference yield:

N-ethyl-3-fluoro-5-iodo-4-methylbenzamide (861905-38-6) → {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid (861905-39-7)

Guidance literature:

N-ethyl-3-fluoro-5-iodo-4-methylbenzamide; With n-butyllithium; Triisopropyl borate; sodium hydride; In tetrahydrofuran; hexanes; at -75 ℃; for 6.08333h;

With water; In tetrahydrofuran; hexanes; at -75 - 15 ℃;

Reference yield:

6-Iodo-1H-indazole (261953-36-0) + {5-[(ethylamino)carbonyl]-3-fluoro-2-methylphenyl}boronic acid (861905-39-7) → N-ethyl-3-fluoro-5-(1H-indazol-6-yl)-4-methylbenzamide (861972-64-7)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; at 150 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

Triisopropyl borate

N-ethyl-3-fluoro-5-iodo-4-methylbenzamide

Downstream raw materials:

N-ethyl-3-fluoro-5-(1H-indazol-6-yl)-4-methylbenzamide