1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole

Base Information

• Chemical Name: 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole
• CAS No.: 221593-49-3
• Molecular Formula: C₂₆H₂₁F₆N₂P
• Molecular Weight: 506.43
• Mol file: 221593-49-3.mol

Synonyms:1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole

Chemical Property of 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole

There total 4 articles about 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-bromobenzyl bromide (823-78-9) → 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole (221593-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) 60 deg C, 48 h

2: 92 percent / Pd(PPh₃)4 / toluene / 8 h / 100 °C

3: AIBN / CH₂Cl₂ / 24 h / Ambient temperature; Irradiation

With 2,2'-azobis(isobutyronitrile); sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/(SICI)1521-3773(19990201)38:3<405::AID-ANIE405>3.0.CO;2-0

Reference yield:

3,5-bis(trifluoromethyl)pyrazole (14704-41-7) → 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole (221593-49-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / NaH / dimethylformamide / 1.) r.t., 2 h, 2.) 60 deg C, 48 h

2: 92 percent / Pd(PPh₃)4 / toluene / 8 h / 100 °C

3: AIBN / CH₂Cl₂ / 24 h / Ambient temperature; Irradiation

With 2,2'-azobis(isobutyronitrile); sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/(SICI)1521-3773(19990201)38:3<405::AID-ANIE405>3.0.CO;2-0

Reference yield:

1-(3-bromo-benzyl)-3,5-bis-trifluoromethyl-1H-pyrazole (221593-58-4) → 1-[3-(2-diphenylphosphanyl-ethyl)-benzyl]-3,5-bis-trifluoromethyl-1H-pyrazole (221593-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Pd(PPh₃)4 / toluene / 8 h / 100 °C

2: AIBN / CH₂Cl₂ / 24 h / Ambient temperature; Irradiation

With 2,2'-azobis(isobutyronitrile); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene;

DOI:10.1002/(SICI)1521-3773(19990201)38:3<405::AID-ANIE405>3.0.CO;2-0

upstream raw materials:

diphenylphosphane

3,5-bis-trifluoromethyl-1-(3-vinyl-benzyl)-1H-pyrazole

meta-bromobenzyl bromide

3,5-bis(trifluoromethyl)pyrazole

Downstream raw materials:

RuCl₂(C₆H₄(CH₂CH₂P(C₆H₅)2)(CH₂(C₃HN₂(CF₃)2)))

RuCl₂(C₆H₄(CH₂CH₂P(C₆H₅)2)(CH₂(C₃HN₂(CF₃)2)))