N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

Base Information

Chemical Name:N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide
CAS No.:172540-15-7
Molecular Formula:C₃₂H₃₅N₃O₄
Molecular Weight:525.648
Hs Code.:

Synonyms:N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

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Chemical Property of N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

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Technology Process of N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

There total 3 articles about N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115886-03-8
3-(benzyloxy)-5-methyl-4-isoxazolecarboxylic acid

: 172540-15-7
N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / SOCl₂, DMF / 0.25 h / Heating

2: 55 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / -78 °C

3: 1.) MeOH, reflux, 30 min, 2.) MeOH, overnight, RT

With thionyl chloride; lithium tri(t-butoxy)aluminum hydride; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1021/jm950393q

Reference yield:

: 172540-12-4
3-(benzyloxy)-5-methyl-4-isoxazolecarbonyl chloride

: 172540-15-7
N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.5 h / -78 °C

2: 1.) MeOH, reflux, 30 min, 2.) MeOH, overnight, RT

With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran;
DOI:10.1021/jm950393q

Reference yield:

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 2627-86-3
(S)-1-phenyl-ethylamine

: 65-85-0,8013-63-6
benzoic acid

: 172540-13-5
3-(benzyloxy)-5-methyl-4-isoxazolecarbaldehyde

: 172540-14-6
N-[(R)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

: 172540-15-7
N-[(S)-(3-Benzyloxy-5-methyl-isoxazol-4-yl)-tert-butylcarbamoyl-methyl]-N-((S)-1-phenyl-ethyl)-benzamide

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given; 1.) MeOH, reflux, 30 min, 2.) MeOH, overnight, RT;
DOI:10.1021/jm950393q