3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

Base Information

Chemical Name:3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine
CAS No.:1620087-88-8
Molecular Formula:C₁₈H₁₆Cl₂F₃NO₂
Molecular Weight:406.232
Hs Code.:

Synonyms:3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

Chemical Property:

Purity/Quality:

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Technology Process of 3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

There total 6 articles about 3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620087-62-8
C₂₃H₂₄Cl₂F₃NO₄

: 1620087-88-8
3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

Guidance literature:: C₂₃H₂₄Cl₂F₃NO₄; With hydrogenchloride; In methanol; water; at 60 ℃; for 12h;

With sodium hydroxide; In methanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2014.06.026

Reference yield:

: 152537-04-7
tert-butyl 3-(2-oxoethyl)azetidine-1-carboxylate

: 1620087-88-8
3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

3.1: hydrogenchloride / methanol; water / 12 h / 60 °C

3.2: 0.5 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2014.06.026

Reference yield:

: 497160-14-2
tert-butyl 3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate

: 1620087-88-8
3-(2-(3,4-dichlorophenyl)-2-(3-(trifluoromethoxy)phenoxy)ethyl)azetidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 - 20 °C / Cooling with ice; Inert atmosphere

2.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 3 h / -78 °C / Cooling with ice; Inert atmosphere

2.2: 1 h / -78 °C

3.1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

5.1: hydrogenchloride / methanol; water / 12 h / 60 °C

5.2: 0.5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2014.06.026