(E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester

Base Information

• Chemical Name: (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester
• CAS No.: 851487-08-6
• Molecular Formula: C₂₂H₂₇NO₅S
• Molecular Weight: 417.526

Synonyms:(E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester

Chemical Property of (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester

There total 1 articles about (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2'R,2E)-3-(1'-tosylaziridin-2'-yl)acrylic methyl ester + 3-phenyl-propionaldehyde (104-53-0) → (E)-(S)-2-((R)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester (851487-02-0) + (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester (851487-08-6)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at -78 ℃; Title compound not separated from byproducts;

DOI:10.1246/cl.2005.372

Reference yield: 54.0%

(E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester (851487-08-6) → N-((E)-(4R,5S)-5-Hydroxy-4-hydroxymethyl-7-phenyl-hept-2-enyl)-4-methyl-benzenesulfonamide

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -20 ℃; for 2h;

DOI:10.1246/bcsj.78.1309

Reference yield:

(E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester (851487-08-6) → N-[(E)-3-((4S,5R)-2,2-Dimethyl-4-phenethyl-[1,3]dioxan-5-yl)-allyl]-4-methyl-benzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / DIBAL / CH₂Cl₂ / 2 h / -20 °C

2: 77 percent / CSA / CH₂Cl₂ / 2 h / 20 °C

With camphor-10-sulfonic acid; diisobutylaluminium hydride; In dichloromethane;

DOI:10.1246/bcsj.78.1309

upstream raw materials:

3-phenyl-propionaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 851487-08-6 (E)-(S)-2-((S)-1-Hydroxy-3-phenyl-propyl)-5-(toluene-4-sulfonylamino)-pent-3-enoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send