N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide
CAS No.:1403479-44-6
Molecular Formula:C₂₇H₃₉FN₄O₅S
Molecular Weight:550.695
Hs Code.:

N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Synonyms:N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Chemical Property of N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

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Technology Process of N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

There total 16 articles about N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: N-(((8R,9R,15S)-6-((2S)-1-azidopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

: 1403479-44-6
N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm500994n

Reference yield: 44.0%

: (((8R,9R,15S)-8,15-dimethyl-5-oxo-6-((S)-1-(2-nitrophenylsulfonamido)propan-2-yl)-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzensulfonamide

: 1403479-44-6
N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 4-fluoro-N-{[(8R,9R,15S)-6-[(2S)-1-hydroxypropan-2-yl]-8,15-dimethyI-5-oxo-5H,6H,7H,8H,9H,11H,12H,13H,14H,15H-pyrido[2,3-b]1,9-dioxa-5-azacyclotetradecan-9-yl]methyl}-N-methylbenzene-1-sulfonamide

: 1403479-44-6
N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.25 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 1.5 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; thiophenol; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;