tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

Base Information

Chemical Name:tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate
CAS No.:680231-52-1
Molecular Formula:C₂₈H₂₈FN₃O₅
Molecular Weight:505.546
Hs Code.:

Synonyms:tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

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Chemical Property of tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

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Technology Process of tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

There total 1 articles about tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: (2,3-cis)-3-amino-2-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride

: 142186-36-5
(S)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid

: 680231-52-1
tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

: C₂₈H₂₈FN₃O₅

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield: 99.0%

: 680231-52-1
tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

: 680231-53-2
(2S)-2-amino-2-(4-fluorophenyl)-N-[(2R,3S)-4oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-acetamide

Guidance literature:: tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 680231-52-1
tert-butyl ((1S)-1-(4-fluorophenyl)-2-oxo-2-{(2R,3S)-[4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]amino}ethyl) carbamate

: 680228-54-0
(2S)-2-[(cyclohexyl)acetyl]amino-2-(4-fluorophenyl)-N-[(2R,3S)-4-oxo-2-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;