4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

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Chemical Name:4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid
CAS No.:1352803-92-9
Molecular Formula:C₂₆H₃₁N₇O₃
Molecular Weight:489.577
Hs Code.:

Synonyms:4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

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Chemical Property of 4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

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Technology Process of 4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

There total 4 articles about 4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.3%

: 100-21-0
terephthalic acid

: 1352804-11-5
N₂-mesityl-N₄-methyl-N₆-(piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine

: 1352803-92-9
4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

Guidance literature:: terephthalic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 0 ℃;

N₂-mesityl-N₄-methyl-N₆-(piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

: 1352804-07-9
6-chloro-N₂-mesityl-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine

: 1352803-92-9
4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 50 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: pH 8

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0 °C

3.2: 20 °C

With sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

: 88-05-1
2,4,6-trimethylaniline

: 1352803-92-9
4-(4-(4-(mesitylamino)-6-(methylamino)-1,3,5-triazin-2-ylamino)piperidine-1-carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 3 h / 0 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water; acetone / 8 h / 30 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 50 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

4.2: pH 8

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0 °C

5.2: 20 °C

With sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2012.02.019