ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

Base Information

Chemical Name:ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate
CAS No.:1263064-69-2
Molecular Formula:C₂₂H₁₉F₂NO₄
Molecular Weight:399.394
Hs Code.:

Synonyms:ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

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Chemical Property of ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

Chemical Property:

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Technology Process of ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

There total 4 articles about ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1263064-52-3
ethyl 4-chloro-2-cyclopropyl-5,6-difluoroquinoline-3-carboxylate

: 150-76-5
4-methoxy-phenol

: 1263064-69-2
ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

Guidance literature:: 4-methoxy-phenol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

ethyl 4-chloro-2-cyclopropyl-5,6-difluoroquinoline-3-carboxylate; In tetrahydrofuran; at 67 ℃; for 6h; regioselective reaction;
DOI:10.1080/00397910903531656

Reference yield:

: diethyl 2?(chloro(cyclopropyl)methylene)malonate

: 1263064-69-2
ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2.1: diphenylether / 0.5 h / 220 °C

2.2: 6 h / 75 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 6 h / 67 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; diphenylether; N,N-dimethyl-formamide;
DOI:10.1080/00397910903531656

Reference yield:

: 1202384-18-6
diethyl [cyclopropyl(3,4-difluorophenylamino)methylene]malonate

: 1263064-69-2
ethyl 2-cyclopropyl-5,6-difluoro-4-(4-methoxyphenyloxy)quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenylether / 0.5 h / 220 °C

1.2: 6 h / 75 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 6 h / 67 °C

With sodium hydride; In tetrahydrofuran; diphenylether;
DOI:10.1080/00397910903531656