carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

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Chemical Name:carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester
CAS No.:1569901-97-8
Molecular Formula:C₂₄H₂₅N₅O₃
Molecular Weight:431.494
Hs Code.:

Synonyms:carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

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Chemical Property of carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

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Technology Process of carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

There total 8 articles about carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1569901-87-6
carbamic acid 3'-methoxy-4'-(1-methyl-prop-2-ynyl)-biphenyl-4-yl ester

: 514854-13-8
2,4-diamino-6-ethyl-5-iodopyrimidine

: 1569901-97-8
carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere; Sealed tube;
DOI:10.1021/jm401916j

Reference yield:

: 2-{4-[4-(but-3-yn-2-yl)-3-methoxyphenyl]phenoxy}oxane

: 1569901-97-8
carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; toluene-4-sulfonic acid / 0 - 20 °C

2: dichloromethane / 0 - 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere; Sealed tube

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm401916j

Reference yield:

: 1-[3-methoxy-4'-(tetrahydro-pyran-2-yloxy)-biphenyl-4-yl]-ethanone

: 1569901-97-8
carbamic acid 4'-[3-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-1-methyl-prop-2-ynyl]-3′-methoxy-biphenyl-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: mercury(II) diacetate / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 0.25 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 2 h / 0 °C / Inert atmosphere

4.1: methanol; toluene-4-sulfonic acid / 0 - 20 °C

5.1: dichloromethane / 0 - 20 °C

6.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere; Sealed tube

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; mercury(II) diacetate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium t-butanolate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 6.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm401916j