1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:195375-47-4
Molecular Formula:C₂₈H₂₇N₃O₄
Molecular Weight:469.54
Hs Code.:

Synonyms:1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 6 articles about 1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 195375-43-0
3'-(Trityl)amino-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxyuridine

: 195375-47-4
1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 16h;
DOI:10.1021/jo970801t

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 195375-47-4
1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / Et₃N, DMAP / dimethylformamide / 1 h / Ambient temperature

2: 90 percent / Ph₃P, DIAD / dimethylformamide / 2 h / Ambient temperature

3: 87 percent / LiN₃ / dimethylformamide / 48 h / 95 - 100 °C

4: 30.4 g / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂

5: 85 percent / Et₃N / pyridine; CH₂Cl₂ / 2 h / Ambient temperature

6: 86 percent / TBAF / tetrahydrofuran / 16 h

With dmap; lithium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970801t

Reference yield:

: 76223-04-6
1-((2R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 195375-47-4
1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / Ph₃P, DIAD / dimethylformamide / 2 h / Ambient temperature

2: 87 percent / LiN₃ / dimethylformamide / 48 h / 95 - 100 °C

3: 30.4 g / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂

4: 85 percent / Et₃N / pyridine; CH₂Cl₂ / 2 h / Ambient temperature

5: 86 percent / TBAF / tetrahydrofuran / 16 h

With lithium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970801t