(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

Base Information

Chemical Name:(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one
CAS No.:1613628-11-7
Molecular Formula:C₂₃H₂₄F₄N₄O₂
Molecular Weight:464.463
Hs Code.:

Synonyms:(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

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Chemical Property of (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

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Technology Process of (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

There total 7 articles about (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1086382-78-6
2-bromo-5-cyclopropylpyrazine

: 1613630-11-7
(8R,9aS)-2-[3-fluoro-4-(trifluoromethyl)benzyl]-8-hydroxyoctahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

: 1613628-11-7
(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1613628-11-7
(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydride / water / 2 h / 50 - 70 °C

2.1: hydrogen / methanol / 6 h / 80 °C / 3102.97 Torr

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

5.1: acetic acid / water / 24 h

6.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; potassium tert-butylate; hydrogen; potassium hydride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1613630-07-1
(8R,9aS)-8-[(triethylsilyl)oxy]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

: 1613628-11-7
(8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: acetic acid / water / 24 h

3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; sodium hydride; acetic acid; In tetrahydrofuran; water; mineral oil;