7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

Base Information

Chemical Name:7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester
CAS No.:78200-05-2
Molecular Formula:C₃₃H₅₁NO₆
Molecular Weight:557.771
Hs Code.:

Synonyms:7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

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Chemical Property of 7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

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Technology Process of 7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

There total 8 articles about 7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52477-97-1
2-(7-butoxycarbonylhexyl)-2-cyclopenten-1-one

: 78200-05-2
7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 2) pyridinium p-toluenesulfonate / 1) tetramethylguanidine

2: 72 percent / PhNCO, NEt₃ / 1) room temperrature, overnight, 2) 50 deg C, 1 h

3: 66 percent / γ-MnO2

4: H₂ / PtO₂, Raney nickel / methanol

5: 1.4 g / pyridine / Ambient temperature

6: NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; manganese(IV) oxide; sodium tetrahydroborate; hydrogen; pyridinium p-toluenesulfonate; phenyl isocyanate; triethylamine; platinum(IV) oxide; 1,1,3,3-tetramethylguanidine; nickel; In methanol;
DOI:10.1021/jo00335a040

Reference yield:

: 78199-98-1
butyl 7β-(nitromethyl)-1,4-dioxaspiro<4.4>nonane-6α-heptanoate

: 78200-05-2
7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / PhNCO, NEt₃ / 1) room temperrature, overnight, 2) 50 deg C, 1 h

2: 66 percent / γ-MnO2

3: H₂ / PtO₂, Raney nickel / methanol

4: 1.4 g / pyridine / Ambient temperature

5: NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; manganese(IV) oxide; sodium tetrahydroborate; hydrogen; phenyl isocyanate; triethylamine; platinum(IV) oxide; nickel; In methanol;
DOI:10.1021/jo00335a040

Reference yield:

: 592-76-7
1-Heptene

: 78200-05-2
7-[(6R,7S)-7-((Z)-1-Benzoylamino-3-hydroxy-oct-1-enyl)-1,4-dioxa-spiro[4.4]non-6-yl]-heptanoic acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / PhNCO, NEt₃ / 1) room temperrature, overnight, 2) 50 deg C, 1 h

2: 66 percent / γ-MnO2

3: H₂ / PtO₂, Raney nickel / methanol

4: 1.4 g / pyridine / Ambient temperature

5: NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; manganese(IV) oxide; sodium tetrahydroborate; hydrogen; phenyl isocyanate; triethylamine; platinum(IV) oxide; nickel; In methanol;
DOI:10.1021/jo00335a040