(+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B

Base Information

• Chemical Name: (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B
• CAS No.: 873070-95-2
• Molecular Formula: C₇₅H₇₂O₈Si₂
• Molecular Weight: 1157.56
• Mol file: 873070-95-2.mol

Synonyms:(+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B

Chemical Property of (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B

There total 7 articles about (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-tert-butyldiphenylsilyloxy-2'-hydroxymethyl-2,4'-methylene diphenol (873070-94-1) + pinocembrin (480-39-7,61490-55-9,68745-38-0) → (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B (873070-95-2)

Guidance literature:

With zinc(II) chloride; In 1,4-dioxane; at 100 ℃; for 22h;

DOI:10.1021/ol052269z

Reference yield:

5,7-bis(methoxymethoxy)-2-phenylchroman-4-one (873070-89-4) → (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B (873070-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrochloric acid / methanol / 0.5 h / Heating

2: 92 percent / ZnCl₂ / dioxane / 22 h / 100 °C

With hydrogenchloride; zinc(II) chloride; In 1,4-dioxane; methanol;

DOI:10.1021/ol052269z

Reference yield:

1-tert-butyldiphenylsilyloxy-2'-hydroxymethyl-2,4'-methylene diphenol (873070-93-0) → (+/-)-2''',2''''-bis(tert-butyldiphenylsilyloxy)-5''-benzylisouvarinol-B (873070-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂O₂ / tetrahydrofuran / 4 h / 0 - 20 °C

2: 92 percent / ZnCl₂ / dioxane / 22 h / 100 °C

With dihydrogen peroxide; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/ol052269z

upstream raw materials:

1-tert-butyldiphenylsilyloxy-2'-hydroxymethyl-2,4'-methylene diphenol

pinocembrin

5,7-bis(methoxymethoxy)-2-phenylchroman-4-one

1-tert-butyldiphenylsilyloxy-2'-hydroxymethyl-2,4'-methylene diphenol