methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Base Information

• Chemical Name: methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate
• CAS No.: 530089-10-2
• Molecular Formula: C₂₅H₂₅ClF₂N₂O₃
• Molecular Weight: 474.935
• Mol file: 530089-10-2.mol

Synonyms:methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Chemical Property of methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate

There total 2 articles about methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate (183171-54-2) + 2-chloro-4-(3-methylpyrrolidin-1-yl)benzoic acid (313674-13-4) → methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate (530089-10-2)

Guidance literature:

2-chloro-4-(3-methylpyrrolidin-1-yl)benzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate; With pyridine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2008.09.039

Reference yield:

→ methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate (530089-10-2)

Guidance literature:

Reference yield:

methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate (530089-10-2) → C24H23ClF2N2O3 (1092770-37-0)

Guidance literature:

methyl (2Z)-{1-[2-chloro-4-(3-methylpyrrolidin-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate; With sodium hydroxide; water; In methanol; at 20 ℃; for 4h;

With hydrogenchloride; In methanol; chloroform; water;

DOI:10.1016/j.bmc.2008.09.039

upstream raw materials:

methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

2-chloro-4-(3-methylpyrrolidin-1-yl)benzoic acid

Downstream raw materials:

C₂₄H₂₃ClF₂N₂O₃