Technology Process of N-Fmoc-Ac6c-Asn-(OtBu)
There total 1 articles about N-Fmoc-Ac6c-Asn-(OtBu) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid;
With
benzotriazol-1-ol; diisopropyl-carbodiimide;
In
N,N-dimethyl-formamide;
for 0.166667h;
L-asparagine 1,1-dimethylethyl ester monohydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm030049q
- Guidance literature:
-
With
piperidine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
DOI:10.1021/jm030049q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 92 percent / piperidine / dimethylformamide / 1 h / 20 °C
2.1: HOAt; EDC*HCl / dimethylformamide / 24 h / 20 °C
3.1: 246 mg / piperidine / dimethylformamide / 2 h
4.1: HOBt; DIPCDI / dimethylformamide / 0.17 h
4.2: 85 percent / dimethylformamide
5.1: 93 percent / CH2Cl2 / 2 h / 20 °C
6.1: 21 percent / N-methylmorpholine; pentafluorophenyl diphenylphosphinate / dimethylformamide / 20 °C
7.1: 51 percent / H2 / Pd/C / methanol / 2068.59 Torr
With
piperidine; 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1,3-di-tert-butylcarbodiimide; pentafluorophenyl diphenyl-phosphinate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030049q
