2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

Base Information

Chemical Name:2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol
CAS No.:179915-27-6
Molecular Formula:C₂₁H₃₀O₃
Molecular Weight:330.467
Hs Code.:

Synonyms:2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

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Chemical Property of 2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

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Technology Process of 2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

There total 15 articles about 2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179915-19-6
(E)-3-((R)-1-Methyl-2-oxo-cyclohexyl)-acrylic acid methyl ester

: 179915-27-6
2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: TsOH / benzene / Heating

2: LiAlH₄ / diethyl ether / 3 h

3: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, 0 deg C, 10 min

4: 1.) nBuLi / 1.) ether, room temperature, 1 h, 2.) ether, 50 min

5: TsOH / acetone; H₂O / 50 °C

6: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 1 h, 2.) THF, 9 h

With lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In diethyl ether; water; acetone; benzene;
DOI:10.1021/jo952253u

Reference yield:

: 40931-12-2
(2,5-Bis-methoxymethoxy-phenyl)-methanol

: 179915-27-6
2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / Ph₃P, CCl₄ / acetonitrile

With tetrachloromethane; triphenylphosphine; In acetonitrile;
DOI:10.1021/jo952253u

Reference yield:

: 2150-46-1
Methyl 2,5-dihydroxybenzoate

: 179915-27-6
2-[(1S,2R,6S)-1-Hydroxy-2,6-dimethyl-2-((E)-4-methyl-penta-1,3-dienyl)-cyclohexylmethyl]-benzene-1,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 1 h, 2.) THF, room temperature, 5 h

2: 10.2 g / LiAlH₄ / diethyl ether / 4 h

3: 59 percent / Ph₃P, CCl₄ / acetonitrile

With tetrachloromethane; lithium aluminium tetrahydride; sodium hydride; triphenylphosphine; In diethyl ether; acetonitrile;
DOI:10.1021/jo952253u