N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

Base Information

Chemical Name:N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide
CAS No.:1356625-87-0
Molecular Formula:C₃₁H₃₂N₆O₂
Molecular Weight:520.634
Hs Code.:

Synonyms:N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

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Technology Process of N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

There total 2 articles about N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356633-38-9
5-bromo-N-(1-(4-cyanobenzyl)piperidin-4-yl)picolinamide

: 224178-67-0
4-[(piperidin-4-yl)oxy]benzonitrile

: 1356625-87-0
N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 105 ℃; for 14h; Inert atmosphere;

Reference yield:

: 30766-11-1
5-bromoisonicotinic acid

: 1353977-72-6,1158365-82-2
4-amino-1-(4-cyanobenzyl)piperidine dihydrochloride

: 1356625-87-0
N-(1-(4-cyanobenzyl)piperidin-4-yl)-5-(4-(4-cyanophenoxy)piperidin-1-yl)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 14 h / 20 °C

2: sodium t-butanolate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 14 h / 105 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; triethylamine; HATU; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;