1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Base Information

Chemical Name:1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone
CAS No.:773073-15-7
Molecular Formula:C₂₆H₄₁BrN₂O₄Si
Molecular Weight:553.612
Hs Code.:

Synonyms:1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Suppliers and Price of 1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

There total 3 articles about 1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 773073-14-6
N-(3-triisopropylsiloxypropyl)urea

: 141-97-9
ethyl acetoacetate

: 1122-91-4
4-bromo-benzaldehyde

: 773073-15-7
1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Guidance literature:: With lithium trifluoromethanesulfonate; In acetonitrile; for 116h; Heating;
DOI:10.1021/ol048946r

Reference yield:

: 773073-13-5
3-(triisopropylsiloxy)propylamine

: 773073-15-7
1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 97.8 percent / 4-dimethylaminopyridine / tetrahydrofuran / 103.5 h / Heating

2: 83.6 percent / LiOTf / acetonitrile / 116 h / Heating

With dmap; lithium trifluoromethanesulfonate; In tetrahydrofuran; acetonitrile; 2: Biginelli reaction;
DOI:10.1021/ol048946r

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 773073-15-7
1-(3-triisopropylsiloxypropyl)-4-(4-bromophenyl)-5-carboethoxy-6-methyl-3,4-dihydropyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 2,6-lutidine / CH₂Cl₂ / 3.5 h / 20 °C

2: 97.8 percent / 4-dimethylaminopyridine / tetrahydrofuran / 103.5 h / Heating

3: 83.6 percent / LiOTf / acetonitrile / 116 h / Heating

With 2,6-dimethylpyridine; dmap; lithium trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; acetonitrile; 3: Biginelli reaction;
DOI:10.1021/ol048946r