methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate

Base Information

• Chemical Name: methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate
• CAS No.: 910824-04-3
• Molecular Formula: C₂₅H₃₃N₃O₄
• Molecular Weight: 439.555

Synonyms:methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate

Chemical Property of methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate

There total 2 articles about methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl (Z)-3-bromo-2-(tert-butoxycarbonylamino)-3-(1H-1,2,4-triazol-1-yl)acrylate (910823-92-6) + phenethylamine (64-04-0) → methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate (910824-04-3)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 18h;

DOI:10.1002/ejoc.200600094

Reference yield:

N-(tert-butoxycarbonyl)-β-(1,2,4-triazol-1-yl)dehydroalanine methyl ester (312319-46-3) → methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate (910824-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-bromosuccinimide / CH₂Cl₂ / 18 h / 20 °C

1.2: 72 percent / Et₃N / CH₂Cl₂ / 1 h

2.1: 87 percent / Et₃N / methanol / 18 h / 20 °C

With N-Bromosuccinimide; triethylamine; In methanol; dichloromethane;

DOI:10.1002/ejoc.200600094

Reference yield: 76.0%

methyl (E)-2-(tert-butoxycarbonylamino)-2-(phenethylamino)-3-(phenethylimino)propanoate (910824-04-3) → methyl 2-(tert-butoxycarbonylamino)-2-(phenethylamino)acetate

Guidance literature:

With silica gel; In dichloromethane; for 1h;

DOI:10.1002/ejoc.200600094

upstream raw materials:

methyl (Z)-3-bromo-2-(tert-butoxycarbonylamino)-3-(1H-1,2,4-triazol-1-yl)acrylate

phenethylamine

N-(tert-butoxycarbonyl)-β-(1,2,4-triazol-1-yl)dehydroalanine methyl ester

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