dibenzyl 3-amino>hexanedioate

Base Information

Chemical Name:dibenzyl 3-amino>hexanedioate
CAS No.:128135-36-4
Molecular Formula:C₃₆H₄₂N₂O₉
Molecular Weight:646.737
Hs Code.:

dibenzyl 3-<N-<Boc-L-Asp(OBzl)>amino>hexanedioate

Synonyms:dibenzyl 3-amino>hexanedioate

Suppliers and Price of dibenzyl 3-amino>hexanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl 3-amino>hexanedioate

Chemical Property:

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Technology Process of dibenzyl 3-amino>hexanedioate

There total 4 articles about dibenzyl 3-amino>hexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 128135-35-3
dibenzyl 3-aminohexanedioate hydrochloride

: 128135-36-4
dibenzyl 3-amino>hexanedioate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 28h; Ambient temperature;
DOI:10.1021/jm00172a009

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 128135-36-4
dibenzyl 3-amino>hexanedioate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -30 deg C, 2.) Et₂O, RT, 19 h

2: 51 percent / silver benzoate, triethylamine / 16 h / Ambient temperature

3: 93 percent / 4 N HCl / dioxane / 8 h / Ambient temperature

4: 67 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 28 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; silver benzoate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00172a009

Reference yield:

: 128135-31-9
4-tert-butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester

: 128135-36-4
dibenzyl 3-amino>hexanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / silver benzoate, triethylamine / 16 h / Ambient temperature

2: 93 percent / 4 N HCl / dioxane / 8 h / Ambient temperature

3: 67 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 28 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; silver benzoate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00172a009