Technology Process of 1-(4-methoxy-2,3-dimethyl-phenyl)-4-pyrazin-2-yl-butan-1-one
There total 6 articles about 1-(4-methoxy-2,3-dimethyl-phenyl)-4-pyrazin-2-yl-butan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-methoxy-2,3-dimethyl-phenyl)-4-pyrazin-2-yl-butan-1-ol;
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 0.75h;
With
sodium hydroxide; ethyl acetate;
In
dichloromethane; water;
at 20 ℃;
for 0.166667h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 9-borabicyclo[3.3.1]nonane dimer / tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 4 h / 20 - 50 °C
1.2: 16 h / 20 - 80 °C
1.3: 0.5 h / 0 - 20 °C
2.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
2.2: 0.17 h / 20 °C
With
9-borabicyclo[3.3.1]nonane dimer; Dess-Martin periodane;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane;
2.1: Jones Oxidation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium on activated carbon / ethanol; ethyl acetate / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -42 - 42 °C
2.2: 2.5 h / 20 - 42 °C
3.1: tetrahydrofuran / 2 h / -78 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 0.75 h / 20 °C
4.2: 0.17 h / 20 °C
With
oxalyl dichloride; hydrogen; Dess-Martin periodane; dimethyl sulfoxide;
palladium on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
2.1: Swern Oxidation / 2.2: Swern Oxidation / 4.1: Jones Oxidation;
