p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:63837-22-9
Molecular Formula:C₁₃H₁₀BrNO₅
Molecular Weight:340.13
Hs Code.:

Synonyms:p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 7 articles about p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 60297-60-1
p-bromobenzyl clavulanate

: 63837-22-9
p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With ozone; In ethyl acetate; at -60 ℃; for 1.5h;

Reference yield: 71.0%

: 63837-22-9
3,7-dioxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-bromo-benzyl ester

Guidance literature:

Reference yield:

: 57943-82-5
methyl clavulanate

: 63837-22-9
p-bromobenzyl (2S,5R)-3,7-dioxo-4-oxa-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / sodium hydroxide / H₂O / 1.17 h / 0 °C

2: 69 percent / dimethylformamide / 1.5 h / Ambient temperature

3: 1.) H₂, sodium hydrogen carbonate / palladium on carbon / 1.) ethanol, ambient temperature, 60 min, 2.) N,N-dimethylformamide, room temperature, 2 h

4: 71 percent / ozone / ethyl acetate / 1.5 h / -60 °C

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; ozone; palladium on activated charcoal; In water; ethyl acetate; N,N-dimethyl-formamide;