tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate
CAS No.:1434271-69-8
Molecular Formula:C₃₀H₃₅N₃O₃
Molecular Weight:485.626
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 807618-13-9
(1-(tert-butoxycarbonyl)piperidine-4-yl)zinc(II) iodide

: 1434271-67-6
3-(4-bromophenyl)-1-(pyridazin-4-yl)-3-o-tolylpropan-1-one

: 1434271-69-8
tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In N,N-dimethyl acetamide; at 85 ℃; for 6h;

Reference yield:

: 34231-77-1
methyl pyridazine-4-carboxylate

: 1434271-69-8
tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropyl amide / ethylbenzene; tetrahydrofuran; n-heptane / 0.08 h / -5 - 0 °C

2: triethylamine / tetrahydrofuran / 6 h / 0 °C

3: copper(l) iodide / diethyl ether; tetrahydrofuran / 1.75 h / 0 °C

4: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 6 h / 85 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; n-heptane; N,N-dimethyl acetamide; ethylbenzene;

Reference yield:

: 1434271-65-4
dimethyl 2-oxo-2-(pyridazin-4-yl)ethylphosphonate

: 1434271-69-8
tert-butyl 4-(4-(3-oxo-3-(pyridazin-4-yl)-1-o-tolylpropyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 6 h / 0 °C

2: copper(l) iodide / diethyl ether; tetrahydrofuran / 1.75 h / 0 °C

3: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl acetamide / 6 h / 85 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide;