(1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol

Base Information

• Chemical Name: (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol
• CAS No.: 91645-98-6
• Molecular Formula: C₁₂H₁₇NO₅S
• Molecular Weight: 287.337
• Mol file: 91645-98-6.mol

Synonyms:(1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol

Chemical Property of (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol

There total 4 articles about (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1RS,2RS)-2-acetylamino-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol (23150-33-6,23150-34-7,27348-35-2,27348-43-2,27348-46-5,60658-37-9) → (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol (91645-98-6)

Guidance literature:

With peracetic acid;

DOI:10.1021/ja01141a074 DOI:10.1021/ja01113a057

Reference yield:

N-[1-hydroxymethyl-2-(4-methanesulfonyl-phenyl)-2-oxo-ethyl]-acetamide (108565-01-1) → (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol (91645-98-6)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol;

DOI:10.1021/ja01113a057

Reference yield:

N-(4-methanesulfonyl-phenacyl)-acetamide (56739-66-3) → (1RS,2RS)-2-acetylamino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol (91645-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic NaHCO₃

2: aluminium isopropylate; isopropyl alcohol

With aluminum isopropoxide; sodium hydrogencarbonate; isopropyl alcohol;

DOI:10.1021/ja01113a057

upstream raw materials:

(1RS,2RS)-2-acetylamino-1-(4-methylsulfanyl-phenyl)-propane-1,3-diol

N-[1-hydroxymethyl-2-(4-methanesulfonyl-phenyl)-2-oxo-ethyl]-acetamide

N-(4-methanesulfonyl-phenacyl)-acetamide

2-amino-1-(4-(methylmercapto)phenyl)ethanone

Downstream raw materials:

(1RS,2RS)-2-amino-1-(4-methanesulfonyl-phenyl)-propane-1,3-diol

(+/-)-Thiamphenicol