Technology Process of phenyl (2-hydroxy-3,5-dimethyl)phenoxyacetate
There total 5 articles about phenyl (2-hydroxy-3,5-dimethyl)phenoxyacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
tetrachloromethane;
for 1h;
under 2844.39 Torr;
Title compound not separated from byproducts.;
DOI:10.1021/jo9915168
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 85 percent / KH / dimethylformamide / 12 h / 0 - 5 °C
2.1: mCPBA; CF3COOH / CH2Cl2 / 5 h / 0 - 5 °C
2.2: 81 percent / aq. KOH / methanol / 12 h
3.1: 90 percent / NaH / dimethylformamide / 12 h
4.1: 81 percent / 1,3-dicyclohexylcarbodiimide; pyridine / CH2Cl2 / 12 h / 20 °C
5.1: H2 / Pd/C / CCl4 / 1 h / 2844.39 Torr
With
pyridine; hydrogen; potassium hydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
1.1: Alkylation / 2.1: Oxidation / 2.2: Hydrolysis / 3.1: Alkylation / 4.1: Condensation / 5.1: Hydrogenolysis;
DOI:10.1021/jo9915168
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / NaH / dimethylformamide / 12 h
2: 81 percent / 1,3-dicyclohexylcarbodiimide; pyridine / CH2Cl2 / 12 h / 20 °C
3: H2 / Pd/C / CCl4 / 1 h / 2844.39 Torr
With
pyridine; hydrogen; sodium hydride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
1: Alkylation / 2: Condensation / 3: Hydrogenolysis;
DOI:10.1021/jo9915168
