8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Base Information

Chemical Name:8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester
CAS No.:860438-11-5
Molecular Formula:C₄₇H₆₈O₅Si₃
Molecular Weight:797.31
Hs Code.:

8-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3,7-bis-(<i>tert</i>-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Synonyms:8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Suppliers and Price of 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

There total 7 articles about 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-oct-4-enoic acid methyl ester

: 860438-11-5
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 48h;
DOI:10.1021/ol0511833

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

: 860438-11-5
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / CSA / CH₂Cl₂; methanol / 6 h / -10 °C

2: 82 percent / Dess-Martin reagent; pyridine / CH₂Cl₂ / 4 h / 20 °C

3: 72 percent / KHMDS / tetrahydrofuran; toluene / -78 - 20 °C

4: 91 percent / H₂ / Pd/C / ethyl acetate / 48 h

With pyridine; camphor-10-sulfonic acid; hydrogen; potassium hexamethylsilazane; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; 3: Julia-Kocienski olefination;
DOI:10.1021/ol0511833

Reference yield:

: 860437-82-7
3-(tert-butyl-diphenyl-silanyloxy)-4-oxo-butyric acid methyl ester

: 860438-11-5
8-(tert-butyl-dimethyl-silanyloxy)-3,7-bis-(tert-butyl-diphenyl-silanyloxy)-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / KHMDS / tetrahydrofuran; toluene / -78 - 20 °C

2: 91 percent / H₂ / Pd/C / ethyl acetate / 48 h

With hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene; 1: Julia-Kocienski olefination;
DOI:10.1021/ol0511833