Technology Process of (4S)-4,6-bis(phenylmethoxy)hexan-2-one
There total 7 articles about (4S)-4,6-bis(phenylmethoxy)hexan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
DOI:10.1021/jo0055436
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / Red-Al / tetrahydrofuran; toluene / 0 °C
2: POCl3 / CH2Cl2 / 4 h / 0 °C
3: NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C
4: 0.26 g / aq. HCl / methanol / 0.08 h / 20 °C
5: SO3-pyridine; Et3N / dimethylformamide; CH2Cl2 / 20 °C
6: tetrahydrofuran / -78 °C
7: 0.19 g / PCC; NaOAc / CH2Cl2 / 20 °C
With
hydrogenchloride; pyridine-SO3 complex; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; pyridinium chlorochromate; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
1: Ring cleavage / 2: Etherification / 3: Alkylation / 4: Hydrogenolysis / 5: Oxidation / 6: Grignard reaction / 7: Oxidation;
DOI:10.1021/jo0055436
- Guidance literature:
-
Multi-step reaction with 6 steps
1: POCl3 / CH2Cl2 / 4 h / 0 °C
2: NaH; Bu4NI / tetrahydrofuran / 24 h / 20 °C
3: 0.26 g / aq. HCl / methanol / 0.08 h / 20 °C
4: SO3-pyridine; Et3N / dimethylformamide; CH2Cl2 / 20 °C
5: tetrahydrofuran / -78 °C
6: 0.19 g / PCC; NaOAc / CH2Cl2 / 20 °C
With
hydrogenchloride; pyridine-SO3 complex; sodium acetate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; pyridinium chlorochromate; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1: Etherification / 2: Alkylation / 3: Hydrogenolysis / 4: Oxidation / 5: Grignard reaction / 6: Oxidation;
DOI:10.1021/jo0055436
