N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Base Information

Chemical Name:N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide
CAS No.:380900-65-2
Molecular Formula:C₂₅H₃₂N₄O₅
Molecular Weight:468.553
Hs Code.:

<i>N</i>-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Synonyms:N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Chemical Property:

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Technology Process of N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

There total 5 articles about N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 380900-65-2
N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / aq. NaOH; Bn(Et)3NCl / CH₂Cl₂ / 1.5 h / Heating

2: methanol / 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: NaCNBH₃; AcOH / methanol

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00462-1

Reference yield:

: 380901-64-4
4-isocyanomethyl-piperidine-1-carboxylic acid tert-butyl ester

: 380900-65-2
N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 20 °C

2: trifluoroacetic acid / CH₂Cl₂

3: NaCNBH₃; AcOH / methanol

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00462-1

Reference yield:

: (2,4-Dimethoxy-benzyl)-[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amine

: 380900-65-2
N-[[(1-isopropyl-piperidin-4-ylmethyl)-carbamoyl]-(2-nitro-phenyl)-methyl]-4-methoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 20 °C

2: trifluoroacetic acid / CH₂Cl₂

3: NaCNBH₃; AcOH / methanol

With sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/S0960-894X(03)00462-1