(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Base Information

Chemical Name:(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid
CAS No.:1073544-08-7
Molecular Formula:C₃₁H₃₇FO₄
Molecular Weight:492.631
Hs Code.:

Synonyms:(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Suppliers and Price of (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

There total 10 articles about (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1073546-21-0
methyl (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoate

: 1073544-08-7
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Guidance literature:: methyl (3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoate; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 23 ℃;

With hydrogenchloride; water; In tetrahydrofuran; methanol;

Reference yield:

: 1073546-13-0
methyl (3R)-3-(3-bromo-4-hydroxyphenyl)hexanoate

: 1073544-08-7
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

3: hydrogen / palladium on activated carbon / ethyl acetate

4: caesium carbonate / N,N-dimethyl-formamide

5: methanol; lithium hydroxide; water / tetrahydrofuran / 23 °C

With methanol; lithium hydroxide; water; hydrogen; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1073545-35-3
methyl (3R)-3-(4-hydroxyphenyl)hexanoate

: 1073544-08-7
(3R)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)-3-methylphenyl)hexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: bromine; acetic acid / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C

4: hydrogen / palladium on activated carbon / ethyl acetate

5: caesium carbonate / N,N-dimethyl-formamide

6: methanol; lithium hydroxide; water / tetrahydrofuran / 23 °C

With methanol; lithium hydroxide; water; hydrogen; bromine; potassium carbonate; caesium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;