[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester
CAS No.:117498-91-6
Molecular Formula:C₁₇H₂₁N₃O₃S
Molecular Weight:347.438
Hs Code.:

Synonyms:[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

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Chemical Property of [5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

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Technology Process of [5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

There total 6 articles about [5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117498-51-8
<4-<<(tert-butoxycarbonyl)amino>methyl>-2-thienyl>(3,4-dinitrophenyl)methanone

: 117498-91-6
[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 45h; Ambient temperature;
DOI:10.1021/jm00122a020

Reference yield:

: 528-45-0
3,4-dinitrobenzoic acid

: 117498-91-6
[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 12 h / Heating

2: AlCl₃ / CH₂Cl₂ / 2.5 h / Heating

3: 78 percent / 45percent sulfuric aicd / 4.5 h / Heating

4: thionyl chloride / 3 h / Heating

5: 1.) azidotrimethylsilane / 1.) toluene, reflux, 16 h, 2.) reflux, 6 h

6: H₂ / 10percent Pd/C / methanol / 45 h / Ambient temperature

With aluminium trichloride; thionyl chloride; trimethylsilylazide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00122a020

Reference yield:

: 24376-18-9
3,4-dinitrobenzoyl chloride

: 117498-91-6
[5-(3,4-Diamino-benzoyl)-thiophen-3-ylmethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / CH₂Cl₂ / 2.5 h / Heating

2: 78 percent / 45percent sulfuric aicd / 4.5 h / Heating

3: thionyl chloride / 3 h / Heating

4: 1.) azidotrimethylsilane / 1.) toluene, reflux, 16 h, 2.) reflux, 6 h

5: H₂ / 10percent Pd/C / methanol / 45 h / Ambient temperature

With aluminium trichloride; thionyl chloride; trimethylsilylazide; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00122a020