4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

Base Information

Chemical Name:4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole
CAS No.:444348-61-2
Molecular Formula:C₁₆H₁₁ClF₃N₃O
Molecular Weight:353.731
Hs Code.:

Synonyms:4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

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Chemical Property of 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

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Technology Process of 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

There total 4 articles about 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 202822-42-2
N-(5-chloro-2-methoxyphenyl)-4-(trifluoromethyl)benzene carbohydrazonamide

: 444348-61-2
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 18h; Heating;
DOI:10.1021/jm010569q

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 444348-61-2
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 18 h / 24 °C

2: PCl₅ / benzene / 3 h / Heating

3: hydrazine / tetrahydrofuran / 1 h / 24 °C

4: 67 percent / p-TsOH / benzene / 18 h / Heating

With phosphorus pentachloride; toluene-4-sulfonic acid; triethylamine; hydrazine; In tetrahydrofuran; benzene;
DOI:10.1021/jm010569q

Reference yield:

: 95-03-4
5-chloro-2-methoxyaniline

: 444348-61-2
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-4H-1,2,4-triazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 18 h / 24 °C

2: PCl₅ / benzene / 3 h / Heating

3: hydrazine / tetrahydrofuran / 1 h / 24 °C

4: 67 percent / p-TsOH / benzene / 18 h / Heating

With phosphorus pentachloride; toluene-4-sulfonic acid; triethylamine; hydrazine; In tetrahydrofuran; benzene;
DOI:10.1021/jm010569q