3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

Base Information

Chemical Name:3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine
CAS No.:1026925-94-9
Molecular Formula:C₂₀H₂₃F₂N₃O₂SSi
Molecular Weight:435.57
Hs Code.:

3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1<i>H</i>-imidazol-2-yl}-pyridine

Synonyms:3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

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Chemical Property of 3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

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Technology Process of 3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

There total 6 articles about 3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4206-67-1
iodo(trimethylsilyl)methane

: 177662-17-8
3-[4-(difluoromethyl)-1-[4-(methylsulfonyl)phenyl]-1H-imidazol-2-yl]pyridine

: 1026925-94-9
3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

Guidance literature:: 3-[4-(difluoromethyl)-1-[4-(methylsulfonyl)phenyl]-1H-imidazol-2-yl]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

iodo(trimethylsilyl)methane; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jm0000719

Reference yield:

: 298204-73-6
N-[4-(methylthio)phenyl]-3-pyridinecarboxamide

: 1026925-94-9
3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaHCO₃ / propan-2-ol / 6 h / 65 °C

2.1: Ac₂O; 4-(dimethylamino)pyridine / 2 h / Heating

3.1: 74 percent / oxone / methanol; H₂O / 1 h

4.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: tetrahydrofuran; hexane / -78 - 20 °C

With dmap; Oxone; acetic anhydride; sodium hydrogencarbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; water; isopropyl alcohol; 1.1: Alkylation / 2.1: Dehydration / 3.1: Oxidation / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1021/jm0000719

Reference yield:

: 298205-02-4
3-[4-difluoromethyl-1-(4-methylsulfanyl-phenyl)-1H-imidazol-2-yl]-pyridine

: 1026925-94-9
3-{4-difluoromethyl-1-[4-(2-trimethylsilanyl-ethanesulfonyl)-phenyl]-1H-imidazol-2-yl}-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 74 percent / oxone / methanol; H₂O / 1 h

2.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

With Oxone; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; water; 1.1: Oxidation / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1021/jm0000719