5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide

Base Information

• Chemical Name: 5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide
• CAS No.: 1024019-05-3
• Molecular Formula: C₁₆H₃₅NO₃Si
• Molecular Weight: 317.544
• Mol file: 1024019-05-3.mol

Synonyms:5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide

Chemical Property of 5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide

There total 1 articles about 5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + 5-hydroxy-pentanoic acid methyl-methoxy-amide (187756-41-8) → 5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide (1024019-05-3)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2010.03.088

Reference yield:

5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide (1024019-05-3) → 2-(3-butenyl)-2-(4-tri-isopropylsilanyloxybutyl)-4,5-bis(phenylsulfonyl)-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran / 2 h / 0 - 20 °C / Reflux

2: hydroxylamine hydrochloride; sodium acetate / water / 8 h / Reflux

3: hydroxylamine hydrochloride; sodium acetate / chloroform / 12 h / 90 °C / Sealed tube

With hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; chloroform; water;

DOI:10.1021/ol8006056

Reference yield:

5-triisopropylsilanyloxy-pentanoic acid methyl-methoxy-amide (1024019-05-3) → 4,5-bis-benzenesulfonyl-2-(2-oxiranylethyl)-2-(4-tri-isopropylsilanyloxybutyl)-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:

Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / tetrahydrofuran / 2 h / 0 - 20 °C / Reflux

2: hydroxylamine hydrochloride; sodium acetate / water / 8 h / Reflux

3: hydroxylamine hydrochloride; sodium acetate / chloroform / 12 h / 90 °C / Sealed tube

4: peracetic acid / water; acetic acid; acetonitrile / 0.5 h / -15 - 0 °C

With peracetic acid; hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; chloroform; water; acetic acid; acetonitrile;

DOI:10.1021/ol8006056

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate

5-hydroxy-pentanoic acid methyl-methoxy-amide