2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

Base Information

Chemical Name:2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester
CAS No.:339541-44-5
Molecular Formula:C₂₁H₁₈N₂O₃S
Molecular Weight:378.452
Hs Code.:

2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid <i>S</i>-pyridin-2-yl ester

Synonyms:2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

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Chemical Property of 2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

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Technology Process of 2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

There total 1 articles about 2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 339541-58-1
2-(benzyloxycarbonyl-methyl-amino)-benzoic acid methyl ester

: 339541-44-5
2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / KOH / H₂O; methanol / 10 h / 65 °C

2: 84 percent / PPh₃P / tetrahydrofuran / 5 h / 20 °C

With potassium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.7164/antibiotics.54.109

Reference yield: 68.0%

: 339541-44-5
2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

: 999-90-6
S-tert-butyl thioacetate

: 339541-45-6
3-[2-(benzyloxycarbonyl-methyl-amino)-phenyl]-3-oxo-thiopropionic acid S-tert-butyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;
DOI:10.7164/antibiotics.54.109

Reference yield:

: 339541-44-5
2-(benzyloxycarbonyl-methyl-amino)-thiobenzoic acid S-pyridin-2-yl ester

: 3-[hydroxy-(2-methylamino-phenyl)-methylene]-5-isopropyl-pyrrolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / LiN(TMS)2 / tetrahydrofuran / 1 h / -78 - 20 °C

2: 75 percent / Et₃N; CuI / tetrahydrofuran / 0.5 h / 20 °C

3: 93 percent / H₂ / Pd/C / ethanol / 1 h / 20 °C

4: NaOMe / methanol / 12 h / Heating

With copper(l) iodide; hydrogen; sodium methylate; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 4: Dieckmann cyclization;
DOI:10.7164/antibiotics.54.109