4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine

Base Information

• Chemical Name: 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine
• CAS No.: 123705-04-4
• Molecular Formula: C₁₇H₁₀N₄O₂
• Molecular Weight: 302.292

Synonyms:4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine

Chemical Property of 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine

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Technology Process of 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine

There total 5 articles about 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetonitrile (123705-03-3) → 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine (123705-04-4)

Guidance literature:

With PPA; at 90 ℃; for 1h;

DOI:10.1002/jhet.5570260246

Reference yield:

sodium 2,3-dicyanoprop-1-en-1-olate → 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine (123705-04-4)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 2 h / Reflux

2: acetic acid / 0.5 h / Reflux

3: sodium ethanolate / 5 h / 20 °C

4: polyphosphoric acid / 1 h / 90 °C

With sodium ethanolate; acetic acid; In ethanol;

DOI:10.1021/jm401466v

Reference yield:

ethyl 3-cyano-2-hydroxy-3-[5-(1H-pyrrol-1-yl)-1-(phenyl)-1H-pyrazol-4-yl]acrylate (123705-03-3) → 4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine (123705-04-4)

Guidance literature:

With polyphosphoric acid; at 90 ℃; for 1h;

DOI:10.1021/jm401466v

upstream raw materials:

α-ethoxyoxalyl-1-phenyl-5-(1-pyrryl)pyrazole-4-acetonitrile

2-[1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl]acetonitrile

2-[5-amino-1-(phenyl)-1H-pyrazol-4-yl]acetonitrile

ethyl 3-cyano-2-hydroxy-3-[5-(1H-pyrrol-1-yl)-1-(phenyl)-1H-pyrazol-4-yl]acrylate

Downstream raw materials:

5-(2-dimethylaminoethyl)-4,6-dioxo-1-phenyl-1,4,5,6-tetrahydropyrazolo<3,4-e>pyrrolo<3,4-g>indolizine

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