ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

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Chemical Name:ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate
CAS No.:928345-37-3
Molecular Formula:C₂₆H₂₆FN₅O₄
Molecular Weight:491.522
Hs Code.:

Synonyms:ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

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Chemical Property of ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

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Technology Process of ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

There total 14 articles about ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 882974-29-0
(RS)-6-[1-bromo-2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one

: 1187575-26-3
ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(hydrazinocarbothioyl)amino]methyl}propanoate

: 928345-37-3
ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

Guidance literature:: (RS)-6-[1-bromo-2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one; ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(hydrazinocarbothioyl)amino]methyl}propanoate; In ethanol; acetic acid; at 60 ℃; for 14h;

With sodium hydrogencarbonate; In water; acetic acid; ethyl acetate;
DOI:10.1021/jm3008008

Reference yield:

: 1397262-08-6
ethyl 3-amino-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)propanoate

: 928345-37-3
ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / toluene / 1 h / Cooling with ice

2: hydrazine hydrate / ethanol / 8 h / 20 - 40 °C

3: ethanol; acetic acid / 14 h / 60 °C

With sodium hydrogencarbonate; hydrazine hydrate; In ethanol; acetic acid; toluene;
DOI:10.1021/jm3008008

Reference yield:

: 1397262-09-7
ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(phenoxycarbothioyl)amino]methyl}propanoate

: 928345-37-3
ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 8 h / 20 - 40 °C

2: ethanol; acetic acid / 14 h / 60 °C

With hydrazine hydrate; In ethanol; acetic acid;
DOI:10.1021/jm3008008