N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Base Information

Chemical Name:N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride
CAS No.:1035189-06-0
Molecular Formula:C₂₂H₂₄N₄O₂*ClH
Molecular Weight:412.919
Hs Code.:

Synonyms:N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

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Chemical Property of N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

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Technology Process of N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

There total 3 articles about N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1035189-29-7
1,1-dimethylethyl 6-{[(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1035189-06-0
N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: 1,1-dimethylethyl 6-{[(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)amino]carbonyl}-3,4-dihydro-2(1H)-isoquinolinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water;

With hydrogenchloride; In methanol;

Reference yield:

: 1035189-17-3
2-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione

: 1035189-06-0
N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / ethanol / 2 h / Heating / reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 48 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; hydrazine; In ethanol; dichloromethane;

Reference yield:

: 1035189-23-1
5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-amine

: 170097-67-3
2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

: 1035189-06-0
N-(5-methyl-1-{[2-(methyloxy)phenyl]methyl}-1H-pyrazol-3-yl)-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 48 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;