7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

Base Information

Chemical Name:7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine
CAS No.:262298-05-5
Molecular Formula:C₁₆H₁₆ClN₃O
Molecular Weight:301.776
Hs Code.:

Synonyms:7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

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Chemical Property of 7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

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Technology Process of 7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

There total 6 articles about 7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 457911-53-4
C₁₆H₁₇N₃O₂

: 262298-05-5
7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With trichlorophosphate; In acetonitrile; at 20 - 80 ℃; for 20 - 30h; Product distribution / selectivity;

Reference yield: 90.0%

: 262298-04-4
2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

: 262298-05-5
7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: With N,N-diethylaniline; trichlorophosphate; In toluene; for 3h; Heating;
DOI:10.1016/S0968-0896(99)00271-0

Reference yield:

: 52289-56-2
1-(bromomethyl)-4-methoxy-2-methylbenzene

: 262298-05-5
7-chloro-2,5-dimethyl-3-(2-methyl-4-methoxyphenyl)pyrazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 23 h / Heating

2: 60 percent / sodium / 16 h / Heating

3: 66 percent / hydrazine monohydrate; acetic acid / toluene / 5 h / Heating

4: 68 percent / acetic acid / 16 h / Heating

5: 90 percent / phosphorus oxychloride; N,N-diethylaniline / toluene / 3 h / Heating

With sodium; hydrazine hydrate; acetic acid; N,N-diethylaniline; trichlorophosphate; In acetic acid; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Condensation / 3: Cyclization / 4: Cyclization / 5: Substitution;
DOI:10.1016/S0968-0896(99)00271-0