4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol

Base Information

• Chemical Name: 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol
• CAS No.: 1307810-44-1
• Molecular Formula: C₂₇H₂₄F₃N₃O₄
• Molecular Weight: 511.5
• Mol file: 1307810-44-1.mol

Synonyms:4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol

Chemical Property of 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol

There total 12 articles about 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(bromomethyl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole (1307812-51-6) + (rac)-3-hydroxymethylmorpholine (106910-83-2) → 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol (1307810-44-1)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

ethyl 5-phenylisoxazole-3-carboxylate (7063-99-2) → 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol (1307810-44-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

5.2: 1.17 h / 0 °C

5.3: 3 h / 110 °C / Inert atmosphere

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / chloroform; water; tetrahydrofuran / 20 °C

6.2: 2 h / 20 °C / Inert atmosphere

7.1: phosphorus tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

8.1: triethylamine / N,N-dimethyl-formamide / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; osmium(VIII) oxide; n-butyllithium; lithium hydroxide monohydrate; phosphorus tribromide; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; trifluoroacetic acid; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

6-Hydroxy-1-tetralone (3470-50-6) → 4-(((3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)morpholino-3-yl)methanol (1307810-44-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

4.2: 1.17 h / 0 °C

4.3: 3 h / 110 °C / Inert atmosphere

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / chloroform; water; tetrahydrofuran / 20 °C

5.2: 2 h / 20 °C / Inert atmosphere

6.1: phosphorus tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: triethylamine / N,N-dimethyl-formamide / 20 °C

With pyridine; osmium(VIII) oxide; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 5-phenylisoxazole-3-carboxylate

6-Hydroxy-1-tetralone

7-(bromomethyl)-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazole

(rac)-3-hydroxymethylmorpholine