(bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

Base Information

Chemical Name:(bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine
CAS No.:1160861-64-2
Molecular Formula:C₃₂H₂₄F₁₂NO₂P
Molecular Weight:713.503
Hs Code.:

Synonyms:(bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

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Chemical Property of (bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

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Technology Process of (bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

There total 3 articles about (bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1160861-80-2
2'-iodo-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

: 142421-57-6
bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine

: 1160861-64-2
(bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

Guidance literature:: 2'-iodo-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Schlenk technique; Cooling with acetone-dry ice; Inert atmosphere;

bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine; With copper(l) chloride; at -78 - 80 ℃; for 16h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1002/anie.201502626

Reference yield:

: 698-00-0
2-bromo-N,N-dimethylaniline

: 82830-49-7
2-fluoro-1,4-dimethoxybenzene

: 1160861-64-2
(bis(trifluoromethyl)phenylphosphanyl)-3',6'-dimethoxy-N,N-dimethyl-[1,1'-biphenyl]-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran; ethylene dibromide / 1.5 h / 70 °C / Schlenk technique; Inert atmosphere

1.2: 1 h / -78 - 20 °C / Cooling with acetone-dry ice; Schlenk technique

1.3: 1 h / 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Schlenk technique; Cooling with acetone-dry ice; Inert atmosphere

2.2: 16 h / -78 - 80 °C / Inert atmosphere; Schlenk technique; Sealed tube

With tert.-butyl lithium; magnesium; In tetrahydrofuran; ethylene dibromide; pentane;
DOI:10.1002/anie.201502626