(3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

Base Information

Chemical Name:(3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine
CAS No.:1159099-72-5
Molecular Formula:C₃₅H₃₇F₂NO₃
Molecular Weight:557.68
Hs Code.:

Synonyms:(3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

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Chemical Property of (3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

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Technology Process of (3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

There total 1 articles about (3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1159099-70-3
(2R,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol

: 100-46-9
benzylamine

: 1159099-72-5
(3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

Guidance literature:: (2R,4R)-2-(benzyloxy)-4-((S)-1,2-bis(benzyloxy)ethyl)-3,3-difluoropentane-1,5-diol; With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

benzylamine; at 80 ℃; for 18h;
DOI:10.1016/j.tet.2009.02.079

Reference yield:

: 1159099-72-5
(3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine

: C₁₄H₁₉F₂NO₃

Guidance literature:: (3R,5R)-1-benzyl-3-(benzyloxy)-5-((S)-1,2-bis(benzyloxy)ethyl)-4,4-difluoropiperidine; With boron trichloride; In n-heptane; dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

With methanol; In n-heptane; dichloromethane;
DOI:10.1016/j.tet.2009.02.079