Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride

Base Information

• Chemical Name: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride
• CAS No.: 172733-79-8
• Molecular Formula: C₁₂H₁₃NO₂*ClH
• Molecular Weight: 239.702
• Hs Code.: 2934999090
• Mol file: 172733-79-8.mol

Synonyms:Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one,hydrochloride (9CI); 3-Oxo-1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]hydrochloride

Chemical Property of Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 2.56650

Purity/Quality:

99%, ^*data from raw suppliers

Spiro[isobenzofuran-1(3H),4''-piperidin]-3-oneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one is a (spiro)(hetero)cyclic amides as modulator of 11-β hydroxysteroid dehydrogenase type 1. Spiro[isobenzofuran-1(3H),4''-piperidin]-3-one is a (spiro)(hetero)cyclic amides as modulator of 11-β hydroxysteroid dehydrogenase type 1.

Technology Process of Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride

There total 3 articles about Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1'-benzylspiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride (54596-01-9) → 3-oxospiro[isobenzofuran-1(3H),4'-piperidine] hydrochloride (172733-79-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; water; at 30 ℃; for 6h; under 1292.9 Torr; Large scale;

DOI:10.1021/op0600963

Reference yield: 85.0%

1'-benzylspiro[isobenzofuran-1(3H),4'-piperidine]-3-one (37663-42-6) → 3-oxospiro[isobenzofuran-1(3H),4'-piperidine] hydrochloride (172733-79-8)

Guidance literature:

With hydrogenchloride; 20% Pd(OH)2/C; hydrogen; In methanol; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2008.08.018

Reference yield:

C15H16ClNO4 → 3-oxospiro[isobenzofuran-1(3H),4'-piperidine] hydrochloride (172733-79-8)

Guidance literature:

With methanol; for 0.5h; Heating / reflux;

upstream raw materials:

1'-benzylspiro[isobenzofuran-1(3H),4'-piperidine]-3-one

1'-benzylspiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 172733-79-8 Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send