N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide
CAS No.:109803-38-5
Molecular Formula:C₁₄H₁₁ClF₃N₃O₂
Molecular Weight:345.708
Hs Code.:

Synonyms:N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

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Technology Process of N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

There total 4 articles about N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 109803-26-1
4-<(3-chlorophenyl)iminomethyl>-1,3-dimethyl-1H-pyrazol-5-ol

: 407-25-0
trifluoroacetic anhydride

: 109803-38-5
N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

Guidance literature:: In ethyl acetate; for 4h; Heating;
DOI:10.1021/jm00393a021

Reference yield:

: 618-46-2
m-Chlorobenzoyl chloride

: 109803-38-5
N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / calcium hydroxide / dioxane / 1.5 h / Heating

2: 82 percent / formamide / 0.33 h / Heating

3: 86 percent / ethyl acetate / 4 h / Heating

With calcium hydroxide; formamide; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00393a021

Reference yield:

: 58011-00-0
(1,3-dimethyl-5-hydroxy-1H-pyrazol-4-yl)(3-chlorophenyl)methanone

: 109803-38-5
N-[1-(3-Chloro-phenyl)-1-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / formamide / 0.33 h / Heating

2: 86 percent / ethyl acetate / 4 h / Heating

With formamide; In ethyl acetate;
DOI:10.1021/jm00393a021