(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Base Information

Chemical Name:(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol
CAS No.:1253197-43-1
Molecular Formula:C₂₆H₂₉NO₃
Molecular Weight:403.521
Hs Code.:

Synonyms:(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

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Technology Process of (+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

There total 7 articles about (+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1253197-26-0
(+/-)-7-benzyloxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

: 588-63-6
3-phenoxypropyl bromide

: 1253197-43-1
(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: With potassium carbonate; In acetonitrile; for 50h; Reflux;
DOI:10.1016/j.bmc.2010.09.026

Reference yield:

: 81593-56-8
[[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid

: 1253197-43-1
(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus pentoxide / 1,2-dichloro-ethane / 24 h / 0 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

2.2: 1 h / Cooling with ice

3.1: potassium carbonate / acetone / 4 h / Reflux

4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

5.1: methanol; magnesium / 5 h / Reflux

6.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 50 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; phosphorus pentoxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; 1,2-dichloro-ethane; acetone; acetonitrile;

Reference yield:

: 81593-57-9
7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one

: 1253197-43-1
(+/-)-7-benzyloxy-3-(3-phenoxypropyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 23 h / Reflux

1.2: 1 h / Cooling with ice

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium tetrahydroborate; methanol / 1 h / 20 °C

4.1: methanol; magnesium / 5 h / Reflux

5.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetonitrile / 50 h / Reflux

With methanol; aluminum (III) chloride; sodium tetrahydroborate; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium; In dichloromethane; acetone; acetonitrile;