3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Base Information

• Chemical Name: 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride
• CAS No.: 603124-28-3
• Molecular Formula: C₂₇H₂₇ClN₂O₅*ClH
• Molecular Weight: 531.436
• Mol file: 603124-28-3.mol

Synonyms:3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Chemical Property of 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride

There total 12 articles about 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H35ClN2O7 → 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride (603124-28-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jm800222k

Reference yield:

(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (132990-84-2) → 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride (603124-28-3)

Guidance literature:

Multi-step reaction with 9 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: iron; ammonium chloride / ethanol; water / 2 h / Reflux

7: pyridine / 2 h / 4 - 20 °C

8: methanol; sodium hydroxide; water / 20 °C

9: hydrogenchloride / 1,4-dioxane / 20 °C

With pyridine; hydrogenchloride; methanol; sodium hydroxide; palladium 10% on activated carbon; water; hydrogen; copper diacetate; boron tribromide; iron; ammonium chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water;

DOI:10.1021/jm800222k

Reference yield:

methyl 3-amino-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate (603124-58-9) → 3-(acetylamino)-5-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoic acid hydrochloride (603124-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 2 h / 4 - 20 °C

2: methanol; sodium hydroxide; water / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

With pyridine; hydrogenchloride; methanol; sodium hydroxide; water; In 1,4-dioxane;

DOI:10.1021/jm800222k

upstream raw materials:

(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

methyl 3-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-nitrobenzoate

methyl 3-amino-5-[((7S)-7-{(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]benzoate

(7S)-7-(benzylamino)-5,6,7,8-tetrahydronaphthalen-2-ol