(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Base Information

Chemical Name:(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde
CAS No.:163594-84-1
Molecular Formula:C₂₂H₂₃IO₆S
Molecular Weight:542.392
Hs Code.:

Synonyms:(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Suppliers and Price of (4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

There total 4 articles about (4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 163594-86-3
[(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-yl]-methanol

: 163594-84-1
(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Guidance literature:: With 3 A molecular sieve; sodium acetate; pyridinium chlorochromate; In dichloromethane; for 0.75h;
DOI:10.1039/c39950000799

Reference yield:

: 163594-85-2
[(4R,5S)-5-(2-Ethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-yl]-methanol

: 163594-84-1
(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / I₂, morpholine / benzene / 2 h / 45 °C

2: 82 percent / PCC, AcONa, molecular sieves 3 Angstroem / CH₂Cl₂ / 0.75 h

With morpholine; 3 A molecular sieve; iodine; sodium acetate; pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1039/c39950000799

Reference yield:

: {2-[(3S,4R)-3,4-Dimethoxy-6-(2-methyl-propane-2-sulfonyl)-3,4-dihydro-2H-pyran-3-ylethynyl]-phenylethynyl}-dimethyl-(1,1,2-trimethyl-propyl)-silane

: 163594-84-1
(4R,5S)-5-(2-Iodoethynyl-phenylethynyl)-4,5-dimethoxy-2-(2-methyl-propane-2-sulfonyl)-5,6-dihydro-4H-pyran-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / LDA / tetrahydrofuran / -78 °C

2: 96 percent / Bu₄NF / tetrahydrofuran / 0.25 h / Ambient temperature

3: 85 percent / I₂, morpholine / benzene / 2 h / 45 °C

4: 82 percent / PCC, AcONa, molecular sieves 3 Angstroem / CH₂Cl₂ / 0.75 h

With morpholine; 3 A molecular sieve; tetrabutyl ammonium fluoride; iodine; sodium acetate; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1039/c39950000799