[2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine

Base Information

• Chemical Name: [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine
• CAS No.: 566168-41-0
• Molecular Formula: C₄₃H₆₈N₄O₉
• Molecular Weight: 785.034
• Mol file: 566168-41-0.mol

Synonyms:[2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine

Chemical Property of [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine

There total 5 articles about [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tris(cyanoethoxymethyl)aminomethane (132491-89-5) → [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine (566168-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine

2: BH₃*THF / dioxane / 55 °C

3: DIPEA

4: TFA / CH₂Cl₂

With borane-THF; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tet.2004.05.105

Reference yield:

[2-(2-cyano-ethoxy)-1,1-bis-(2-cyano-ethoxymethyl)-ethyl]-carbamic acid tert-butyl ester (566168-32-9) → [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine (566168-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: BH₃*THF / dioxane / 55 °C

2: DIPEA

3: TFA / CH₂Cl₂

With borane-THF; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tet.2004.05.105

Reference yield:

[2-(3-amino-propoxy)-1,1-bis-(3-amino-propoxymethyl)-ethyl]-carbamic acid tert-butyl ester (247171-04-6) → [2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}-ethyl]amine (566168-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: DIPEA

2: TFA / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2004.05.105

upstream raw materials:

tris(cyanoethoxymethyl)aminomethane

[2-(2-cyano-ethoxy)-1,1-bis-(2-cyano-ethoxymethyl)-ethyl]-carbamic acid tert-butyl ester

[2-(3-amino-propoxy)-1,1-bis-(3-amino-propoxymethyl)-ethyl]-carbamic acid tert-butyl ester

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione

Downstream raw materials:

[2-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]-propoxy}-1,1-bis-{3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]propoxymethyl}ethyl]isocyanate